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Rabbit Anti-Human MARVELD2 monoclonal antibody, clone 65I20M49

Cat no: CABT-L1468

Rabbit Anti-Human MARVELD2 monoclonal antibody, clone 65I20M49

Rabbit Anti-Human MARVELD2 monoclonal antibody for FC, ICC, IP, IF, WB. Tight junctions form an important barrier of paracellular transport in epithelial cells. Sealing of two adjacent cells at bicellular tight junctions, a point where three adjacent cells are in contact with each other. Tricellulin is the first protein identified that specifically concentrates in tricellular tight junctions. This protein has four membrane spanning domains, similarly to claudins. Tricellulin expression is high in epithelium-derived tissues, such as small intestine, kidney and lung. Functional evidence for the role of tricellulin in tight junction formation comes from siRNA studies, where suppression of its expression leads to compromised epithelial barrier and tight junction formation. Loss of function in tricellulin mutants missing all or most of a conserved region in the cytosolic domain which binds to the cytosolic scaffolding protein ZO-1, indicate that interaction with other known tight junction proteins plays an important role for the function of tricellulin.

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SPECIFICATIONS

Catalog Number

CABT-L1468

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

65I20M49

Target

MARVELD2

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Maintain refrigerated at 2-8В°C for up to 1 month. For long term storage store at -20В°C

SUPPLIER INFO

Creative Diagnostics

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