Rabbit Anti-Human MDM2 monoclonal antibody for ICC, IF, WB. MDM2 also known as murine double minute 2, is found to interact with p53; a tumor suppressor protein, and has been shown to negatively regulate its function. MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and in turn decrease its tumor suppressor function. Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity. MDM2 also plays various important roles in apoptosis and cell cycle. MDM2 is located on chromosome 12 on the q arm.