Rabbit Anti-Human MEK1 (phospho Thr386) monoclonal antibody for ICC, IF, WB. MEK1/mitogen activated protein kinase kinase/ERK kinase 1/microtubule-associated protein 2 kinase is a dual specificity kinase and catalyses both a threonine and a tyrosine residue on MAP kinases ERK1 and ERK2. Mek1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in the signaling during stress activate response, apoptosis and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.