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Rabbit Anti-Human MGMT monoclonal antibody, clone KK190-7

Rabbit Anti-Human MGMT monoclonal antibody, clone KK190-7

Cat no: CABT-L837

Supplier: Creative Diagnostics
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Rabbit Anti-Human MGMT monoclonal antibody for WB, IHC. MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation, only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, high MGMT activity was associated with the presence of mutant p53, in a study of oral cancer cell lines. Similarly, MGMT activity was significantly lower in ovarian tumors with wildtype p53 than in tumors with mutant p53, supporting the view that wildtype p53 down-regulates the basal MGMT promoter.
Catalogue number: CABT-L837
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: KK190-7
Gene: 4255
Target: MGMT
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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