Rabbit Anti-Human MMP-1 polyclonal antibody for IHC-P. Matrix metalloproteinases (MMP) are proteolytic enzymes capable of degrading connective tissue components. Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs) is implicated in the invasive potential of malignant tumors. Interstitial collagenase (MMP-1) , 72kDa gelatinase A / type IV collagenase (MMP-2) , and 92kDa gelatinase B / type IV collagenase (MMP-9) dissolve extracellular matrix (ECM) and may initiate and promote angiogenesis. ****