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Rabbit Anti-Human MMP14 polyclonal antibody

Rabbit Anti-Human MMP14 polyclonal antibody

Cat no: CABT-L1796

Supplier: Creative Diagnostics
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Rabbit Anti-Human MMP14 polyclonal antibody for IHC-P. MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of the matrix metalloproteinase family, ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively, contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2 forming a trimer. It cleaves the pro-MMP-2 to its active form.
Catalogue number: CABT-L1796
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Gene: 4323
Target: MMP14
Isotype: IgG
Clonality: Polyclonal
Storage temp: 2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

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