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Rabbit Anti-Human MNK1 (phospho Thr197, Thr202) monoclonal antibody, clone 29I5M22

Cat no: CABT-L1477

Rabbit Anti-Human MNK1 (phospho Thr197, Thr202) monoclonal antibody, clone 29I5M22

Rabbit Anti-Human MNK1 (phospho Thr197, Thr202) monoclonal antibody for FC, ICC, IHC-P, IF. MAP kinase-interacting serine/threonine kinases (Mnk) function in signal transduction pathways through phosphorylation of eIF4E and are directly phosphorylated by ERK or p38 MAP kinases. In human and mouse there are two Mnk genes. Mnk1 is activated by phosphorylation at Thr197 and Thr202. Mnk1 and Mnk2 are essential for the phosphorylation of eIF4E at Ser209 however they differ markedly in their activity and regulatory patterns. Mnk1 is responsible for inducible phosphorylation of eIF4E while Mnk2 is responsible for basal levels of phosphorylation. Additionally, Mnk2 binds phosphorylated ERK while Mnk2 cannot. Mnk1 has been implicated in signaling in response to oxidative stress by increasing eIF4E phosphorylation upon H2O2 treatment in mice. Oxidative stress induced Mnk1 activity has also been linked to hyperproliferative diseases through the over-activation of eIF4E. Reactivity with Mnk2 has not been tested.

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SPECIFICATIONS

Catalog Number

CABT-L1477

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

29I5M22

Target

MKNK1

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Maintain refrigerated at 2-8В°C for up to 1 month. For long term storage store at -20В°C

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