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Rabbit Anti-Human MSK1 monoclonal antibody, clone 5I26M62

Cat no: CABT-L1579

Rabbit Anti-Human MSK1 monoclonal antibody, clone 5I26M62

Rabbit Anti-Human MSK1 monoclonal antibody for ICC, IF, WB. MSK-1 is a mitogen and stress activated protein kinase-1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK-1 can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG-14 in response to mitogen and stress. Similar to RSK, MSK-1 contains two kinase domains (N-term and a C-term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK-1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C-terminal kinase domain of MSK-1 which is essential for the catalytic activity of the N-terminal kinase domain.

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SPECIFICATIONS

Catalog Number

CABT-L1579

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

5I26M62

Target

RPS6KA5

Gene Id

9252

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C, Avoid Freeze/Thaw Cycles

SUPPLIER INFO

Creative Diagnostics

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