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Rabbit Anti-Human MYB monoclonal antibody, clone TA15-92

Cat no: CABT-L596

Rabbit Anti-Human MYB monoclonal antibody, clone TA15-92

Rabbit Anti-Human MYB monoclonal antibody for WB, ICC/IF, IHC, FC. The Myb family of transcription factors regulates proliferation, differentiation and apoptosis of hematopoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear and binds to specific DNA sequences. The gene encoding for v-Myb is oncogenic, causing monoblastic leukemia and transforming myelomonocytic cells by deregulating the expression of specific target genes. v-Myb functions as a transcriptional activator, and it can repress biologically relevant genes such as Ets-2, which promotes macrophage differentiation. The proto-oncogene c-Myb encodes for a nuclear protein that plays a role in transcriptional regulation and may be essential for hematopoietic cell proliferation. A-Myb is also member of the Myb family that is expressed in proliferating B cell centroblasts. Transgenic mice overexpressing A-Myb posses enhanced hyperplasia of the lymph nodes.

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SPECIFICATIONS

Catalog Number

CABT-L596

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TA15-92

Target

MYB

Gene Id

4602

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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