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Rabbit Anti-Human MyD88 monoclonal antibody, clone TD76-15

Cat no: CABT-L717

Rabbit Anti-Human MyD88 monoclonal antibody, clone TD76-15

Rabbit Anti-Human MyD88 monoclonal antibody for WB, ICC/IF, IHC, FC. Interleukin-1 (IL-1)-induced activation of the NF?B pathway is mediated through the IL-1 receptor and the subsequent phosphorylation of IL-1 receptor-associated kinase (IRAK). The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophilia, and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NF?B activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.

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SPECIFICATIONS

Catalog Number

CABT-L717

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TD76-15

Target

MyD88

Gene Id

4615

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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