Rabbit Anti-Human NCSTN Polyclonal Antibody

Rabbit Anti-Human NCSTN Polyclonal Antibody for IHC. This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimers disease; however, the nature of the encoded proteins role in Alzheimers disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]

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SPECIFICATIONS

Catalog Number

DPABH-09835

Hosts

Rabbit

Reactivities

Hum

Target

NCSTN

Gene Id

23385

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Store at +4В°C for short term storage. Long time storage is recommended at -20В°C. Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.