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Rabbit Anti-Human NFkB p52 monoclonal antibody, clone F.323.2

Cat no: CABT-L1496

Rabbit Anti-Human NFkB p52 monoclonal antibody, clone F.323.2

Rabbit Anti-Human NFkB p52 monoclonal antibody for FC, IHC-P, WB. NF-kappaB (Nuclear Factor kappa B) is a nuclear transcription factor found in all cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, and bacterial or viral antigens. NF-kappaB plays a key role in regulating the immune response to infection. Consistent with this role, incorrect regulation of NF-kappaB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection and improper immune development. There are five members in the NF-kappaB family: NF-kappaB1, NF-kappaB2, RelA (also named p65), RelB, and c-Rel. The most common form of NF-kappaB is the p50/RelA heterodimer, although other forms of NF-kappaB dimers, such as p50/p50, p52/p52, p52/RelA, p50/c-Rel, c-Rel/c-Rel, p52/RelB, and p50/RelB, have also been identified in some types of cells. The primary role of NF-kappaB is to maintain normal cellular functions that range from cell-to-cell communication to cell motility, cell cycle progression, and cell lineage development. The activity of NF-kappaB is tightly regulated by interaction with inhibitory IkappaB proteins.

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SPECIFICATIONS

Catalog Number

CABT-L1496

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

F.323.2

Target

NFKB2

Gene Id

4791

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C

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