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Rabbit Anti-Human NOTCH3 monoclonal antibody, clone 5I6M28

Cat no: CABT-L1500

Rabbit Anti-Human NOTCH3 monoclonal antibody, clone 5I6M28

Rabbit Anti-Human NOTCH3 monoclonal antibody for WB. NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

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SPECIFICATIONS

Catalog Number

CABT-L1500

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

5I6M28

Target

NOTCH3

Gene Id

4854

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C, Avoid Freeze/Thaw Cycles

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