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Rabbit Anti-Human OPN-R monoclonal antibody, clone 35I6M4

Cat no: CABT-L1507

Rabbit Anti-Human OPN-R monoclonal antibody, clone 35I6M4

Rabbit Anti-Human OPN-R monoclonal antibody for FC, ICC, IF, WB. Osteopontin is a 34kDa extracellular matrix protein with a cell binding domain. It was originally identified as a major component of the non-collagenous organic bone matrix, however, it has subsequently been demonstrated in a wide range of normal adult tissue and body fluids. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.

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SPECIFICATIONS

Catalog Number

CABT-L1507

Hosts

Rabbit

Reactivities

Hum, Mouse

Conjugates

Unconj

Clone

35I6M4

Target

OPN

Gene Id

6696

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at 4В°C short term. For long term storage, store at -20В°C, avoiding freeze/thaw cycles.

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