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Rabbit Anti-Human PDCD1 monoclonal antibody, clone TK12-02

Rabbit Anti-Human PDCD1 monoclonal antibody, clone TK12-02

Cat no: DCABH-3351

Supplier: Creative Diagnostics
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Rabbit Anti-Human PDCD1 monoclonal antibody for WB, IHC. Pdcd-1 (Programmed Cell Death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. Pdcd-1 contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) within the cytoplasmic domain, which is conserved between the mouse and human homologs. Expression of Pdcd-1 is detected in mouse thymus, and it is induced in stimulated B and T cell lines, where it may play a role in the negative regulation of various immune responses. Receptors such as Pdcd-1 function by recruiting tyrosine phosphatases, including SHP-1 and SHIP, which are responsible for altering various B cell responses. Additionally, in activated lymphocytes, Pdcd-1 mediates the activation of the classical type of programmed cell death.
Catalogue number: DCABH-3351
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: TK12-02
Gene: 5133
Target: PDCD1
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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