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Rabbit Anti-Human PDPK1 (phospho Ser241) monoclonal antibody, clone L.535.3

Rabbit Anti-Human PDPK1 (phospho Ser241) monoclonal antibody, clone L.535.3

Cat no: CABT-L1526

Supplier: Creative Diagnostics
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Rabbit Anti-Human PDPK1 (phospho Ser241) monoclonal antibody for IP, WB. PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of hosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Catalogue number: CABT-L1526
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Conjugates: Unconjugated
Clone: L.535.3
Gene: 5170
Target: PDPK1
Isotype: IgG
Clonality: Monoclonal
Storage temp: -20°C

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