Rabbit Anti-Human LRRK2 (phospho Ser935) monoclonal antibody for ICC, IHC-P, IF, WB. LRRK2 belongs to the leucine-rich repeat kinase family commonly known as Dardarin. The LRRK2 gene encodes for a protein with an ankyrin-repeat region, a leucine-rich repeat region, a kinase domain, a RAS domain, a GTPase-domain, a MLK-like domain, and a WD40 domain. Proteins with leucine-rich regions play important roles in activities that require protein-protein interactions, such as transmitting signals or helping to assemble the cell's structural framework. Phosphorylation of LRRK2 at multiple sites including serine 910 and serine 935 regulates LRRK2 mediated cellular activities by affecting binding of dimeric 14-3-3 protein. Phosphorylation at Ser910, found to be constitutive in various tissues, is caused by protein kinase A. In humans, he gene is present on the q arm of chromosome 12.