Rabbit Anti-Human Phospholamban (phospho Ser16, Ser17) monoclonal antibody, clone 9 I5M7

Cat no: CABT-L1533

Supplier: Creative Diagnostics

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Rabbit Anti-Human Phospholamban (phospho Ser16, Ser17) monoclonal antibody for WB. Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1-25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases; whereas the transmembrane domain (residues 25-52) is mostly hydrophobic, protease resistant and stabilizes the pentamer. Following adrenergic stimulation of cardiac muscle, PLB is phosphorylated at Ser16 and at Thr17 which is correlated with stimulation of calcium transport activity across the SR membrane and relaxation of cardiac fibers. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.

Catalogue number:	CABT-L1533
Reactivities:	Mouse, Rat
Hosts:	Rabbit
Conjugates:	Unconjugated
Clone:	9 I5M7
Gene:	5350
Target:	PLN
Isotype:	IgG
Clonality:	Monoclonal
Storage temp:	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

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Rabbit Anti-Human Phospholamban (phospho Ser16, Ser17) monoclonal antibody, clone 9 I5M7

Cat no: CABT-L1533

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