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Rabbit Anti-Human PMS2 monoclonal antibody, clone TZ19-10

Cat no: CABT-L606

Rabbit Anti-Human PMS2 monoclonal antibody, clone TZ19-10

Rabbit Anti-Human PMS2 monoclonal antibody for WB, ICC/IF, IHC, IP, FC. The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.

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SPECIFICATIONS

Catalog Number

CABT-L606

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TZ19-10

Target

PMS2

Gene Id

5395

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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