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Rabbit Anti-Human PRKAA1 monoclonal antibody, clone TE1921

Cat no: DCABH-2646

Rabbit Anti-Human PRKAA1 monoclonal antibody, clone TE1921

Rabbit Anti-Human PRKAA1 monoclonal antibody for WB, ICC/IF, IP. AMPK (5'-AMP-activated protein kinase) is a heterotrimeric complex comprising a catalytic ? subunit and regulatory ? and ? subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming bio-synthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxy-methylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. AMPK?1 (5'-AMP-activated protein kinase catalytic subunit alpha-1), also known as PRKAA1, is a 559 amino acid protein that belongs to the CAMK Ser/Thr protein kinase family and protein kinase superfamily. Highly phosphorylated, AMPK?1 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 5p13.1.

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SPECIFICATIONS

Catalog Number

DCABH-2646

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TE1921

Target

PRKAA1

Gene Id

5562

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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