Rabbit Anti-Human PSME3 monoclonal antibody for FC, ICC, IHC-P, IF, WB. PA28 alpha and PA28 beta are located primarily in the cytoplasm, whereas PA28 gamma is located in the nucleus. PA28 binds to the outer rings on both ends of the 20S proteasome to form a football-like structure. Binding of PA28 greatly stimulates multiple peptidase activities of the 20S proteasome in an ATP-independent reaction, but lacks the ability to degrade large protein substrates, suggesting that PA28 may cooperate with the 26 S proteasome in a sequential proteolytic pathway. In addition to its nuclear localization, PA28 gamma differs from PA28 alpha and PA28 beta in that it is not responsive to stimulation with IFN- gamma. Experiments with mice lacking the PA28 gamma gene core protein, which targets HCV for degradation, and with MEKK3, which phosphorylates PA28 gamma and increases its cellular levels. PA28 gamma also acts to increase resistance to apoptosis by promoting MDM2-mediated degradation of p53.
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