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Rabbit Anti-Human RCC1 polyclonal antibody

Cat no: DCABH-7133


Supplier: Creative Diagnostics
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Rabbit Anti-Human RCC1 polyclonal antibody for IHC-P. RCC1 is called Regulator of Chromosome Condensation 1. Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis. The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin. RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1, with chromatin, but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, and, where bound, to increase the affinity of chromatin for NE membranes.
Catalogue number: DCABH-7133
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Gene: 1104
Target: RCC1
Isotype: IgG
Clonality: Polyclonal
Storage temp: 2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

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