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Rabbit Anti-Human RIP3 monoclonal antibody, clone 32I78M4

Cat no: CABT-L1570

Rabbit Anti-Human RIP3 monoclonal antibody, clone 32I78M4

Rabbit Anti-Human RIP3 monoclonal antibody for WB. RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.

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SPECIFICATIONS

Catalog Number

CABT-L1570

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

32I78M4

Target

RIPK3

Gene Id

11035

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C, Avoid Freeze/Thaw Cycles

SUPPLIER INFO

Creative Diagnostics

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