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Rabbit Anti-Human S100P monoclonal antibody, clone KG06-19

Cat no: CABT-L894

Rabbit Anti-Human S100P monoclonal antibody, clone KG06-19

Rabbit Anti-Human S100P monoclonal antibody for WB, ICC/IF, IHC, IP. S-100 proteins are small dimeric members of the EF-Hand superfamily that participate in moderating intracellular calcium signals by binding to and regulating specific proteins in a calcium-dependent manner. S-100P is a survival factor that is associated with different types of tumors and can bind and regulate effector proteins. R1881, a synthetic androgen, regulates S-100P expression. S-100P interacts with a receptor for advanced glycation end products (RAGE) and activates it, thereby increasing the rates of cell growth, division, migration and invasion. This suggests that S-100P acts in an auto-crine manner through RAGE to trigger cell proliferation and survival. S-100P may also positively affect anchorage-independent growth to improve tumor formation. S-100P monomers strongly interact with one another, but not with other S-100 polypeptides, suggesting that homodimer formation is necessary for S-100P to function. The S-100P dimers are then stabilized by hydrophobic contacts.

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SPECIFICATIONS

Catalog Number

CABT-L894

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

KG06-19

Target

S100P

Gene Id

6286

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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