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Rabbit Anti-Human SHIP1 monoclonal antibody, clone K.682.6

Cat no: CABT-L1415

Rabbit Anti-Human SHIP1 monoclonal antibody, clone K.682.6

Rabbit Anti-Human SHIP1 monoclonal antibody for FC, IP, WB. This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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SPECIFICATIONS

Catalog Number

CABT-L1415

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

K.682.6

Target

INPP5D

Gene Id

3635

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C

SUPPLIER INFO

Creative Diagnostics

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