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Rabbit Anti-Human SLC12A5 polyclonal antibody

Cat no: CABT-L1900

Rabbit Anti-Human SLC12A5 polyclonal antibody

Rabbit Anti-Human SLC12A5 polyclonal antibody for IHC. Potassium-chloride transporter member 5 (aka: KCC2 and SLC12A5) is a neuron-specific chloride potassium symporter responsible for establishing the chloride ion gradient in neurons through the maintenance of low intracellular chloride concentrations. It is a critical mediator of synaptic inhibition, cellular protection against excitotoxicity and may also act as a modulator of neuroplasticity. Potassium-chloride transporter member 5 is also known by the names: KCC2 (potassium chloride cotransporter 2) for its ionic substrates, and SLC12A5 for its genetic origin from the SLC12A5 gene in humans. Animals with reduced expression of this transporter exhibit severe motor deficits, epileptiform activity, and spasticity. KCC2 knockout animals, in which KCC2 is completely absent, die postnatally due to respiratory failure.

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SPECIFICATIONS

Catalog Number

CABT-L1900

Hosts

Rabbit

Conjugates

Unconj

Target

SLC12A5

Gene Id

171373

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Store at +4В°C for short term storage. Long time storage is recommended at -20В°C. Avoid Freeze/Thaw Cycles. Do not aliquot the antibody.

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