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Rabbit Anti-Human SMURF2 monoclonal antibody, clone 5I29M28

Rabbit Anti-Human SMURF2 monoclonal antibody, clone 5I29M28

Cat no: CABT-L1600

Supplier: Creative Diagnostics
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Rabbit Anti-Human SMURF2 monoclonal antibody for ICC, IF, WB. SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Catalogue number: CABT-L1600
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: 5I29M28
Gene: 64750
Target: SMURF2
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

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