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Rabbit Anti-Human SMURF2 monoclonal antibody, clone 5I29M28

Cat no: CABT-L1600

Rabbit Anti-Human SMURF2 monoclonal antibody, clone 5I29M28

Rabbit Anti-Human SMURF2 monoclonal antibody for ICC, IF, WB. SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

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SPECIFICATIONS

Catalog Number

CABT-L1600

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

5I29M28

Target

SMURF2

Gene Id

64750

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at 4В°C short term. For long term storage, store at -20В°C, avoiding freeze/thaw cycles.

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