Rabbit Anti-Human SOCS3 polyclonal antibody

Cat no: CABT-L1851

Supplier: Creative Diagnostics

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Rabbit Anti-Human SOCS3 polyclonal antibody for IHC-P. Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling) . To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

Catalogue number:	CABT-L1851
Reactivities:	Human
Hosts:	Rabbit
Conjugates:	Unconjugated
Gene:	9021
Target:	SOCS3
Isotype:	IgG
Clonality:	Polyclonal
Storage temp:	2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

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Rabbit Anti-Human SOCS3 polyclonal antibody

Cat no: CABT-L1851

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