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Rabbit Anti-Human SP1 monoclonal antibody, clone KG1061

Cat no: CABT-L860

Rabbit Anti-Human SP1 monoclonal antibody, clone KG1061

Rabbit Anti-Human SP1 monoclonal antibody for WB, ICC/IF, IHC. Sp1 is a sequence-specific transcription factor that recognizes GGGGCGGGGC and closely related sequences, which are often referred to as GC boxes. Sp1 was initially identified as a HeLa cell-derived factor that selectively activates in vitro transcription from the SV40 promoter and binds to the multiple GC boxes in the 21-bp repeated elements in SV40. The sequence specificity of DNA binding is conferred by Zn (II) fingers, whereas a different region of Sp1 appears to regulate the affinity of DNA binding. Sp1 belongs to a subgroup of transcription factors that are phosphorylated upon binding to promoter sequences. Evidence suggests that the early growth response gene, Erg-1 (also known as Zif268 or NGF1-A), may downregulate certain mammalian gene promoters by competing with Sp1 for binding to an overlapping binding motif. The gene encoding human Sp1 maps to chromosome 12q13.1.

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SPECIFICATIONS

Catalog Number

CABT-L860

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

KG1061

Target

SP1

Gene Id

6667

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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