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Rabbit Anti-Human Syk (phospho Tyr323, Tyr317) monoclonal antibody, clone 7I59M34

Rabbit Anti-Human Syk (phospho Tyr323, Tyr317) monoclonal antibody, clone 7I59M34

Cat no: CABT-L1619

Supplier: Creative Diagnostics
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Rabbit Anti-Human Syk (phospho Tyr323, Tyr317) monoclonal antibody for IF, WB. Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI). This trigges the phosphorylation of downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
Catalogue number: CABT-L1619
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: 7I59M34
Gene: 6850
Target: SYK
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

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