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Rabbit Anti-Human TAB1 monoclonal antibody, clone G.322.7

Cat no: CABT-L1460

Rabbit Anti-Human TAB1 monoclonal antibody, clone G.322.7

Rabbit Anti-Human TAB1 monoclonal antibody for IP, WB. The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

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SPECIFICATIONS

Catalog Number

CABT-L1460

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

G.322.7

Target

MAP3K7IP1

Gene Id

10454

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C

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