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Rabbit Anti-Human Tau (phospho Thr231) monoclonal antibody, clone 2I7M7

Rabbit Anti-Human Tau (phospho Thr231) monoclonal antibody, clone 2I7M7

Cat no: CABT-L1624

Supplier: Creative Diagnostics
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Rabbit Anti-Human Tau (phospho Thr231) monoclonal antibody for ICC, IHC-P, IF, WB. Tau protein plays a very important role in nucleation and stabilization of microtubules by associating with tubulin subunits. In humans, Tau is predominantly expressed in the brain, and is involved in neurodegeneration when the protein is misfolded, hyperphosphorylated, or self-assembles into tangles. Six isoforms of Tau with varying degree of affinity to tubulin exist. Numerous serine/threonine kinases, including GSK-3 beta, protein kinase A, and casein kinase II (CK2) phosphorylate Tau. Phosphorylation of the serine 396 residue is triggered through GSK-3beta and cdk5. The gene encoding the Tau protein consists of 16 exons, and is located at chromosomal locus 17q21.
Catalogue number: CABT-L1624
Reactivities: Human, Rat
Hosts: Rabbit
Conjugates: Unconjugated
Clone: 2I7M7
Gene: 4137
Target: Tau
Isotype: IgG
Clonality: Monoclonal
Storage temp: Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

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