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Rabbit Anti-Human TCF7L2 monoclonal antibody, clone F.009.3

Cat no: CABT-L1631

Rabbit Anti-Human TCF7L2 monoclonal antibody, clone F.009.3

Rabbit Anti-Human TCF7L2 monoclonal antibody for ChIP, IP, WB. TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.

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SPECIFICATIONS

Catalog Number

CABT-L1631

Applications

ChIP

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

F.009.3

Target

TCF7L2

Gene Id

6934

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C

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