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Rabbit Anti-Human Thymidylate Synthase monoclonal antibody, clone TQ223

Rabbit Anti-Human Thymidylate Synthase monoclonal antibody, clone TQ223

Cat no: DCABH-165

Supplier: Creative Diagnostics
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Rabbit Anti-Human Thymidylate Synthase monoclonal antibody for IHC-P. Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma.
Catalogue number: DCABH-165
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: TQ223
Gene: 7298
Target: TYMS
Isotype: IgG
Clonality: Monoclonal
Storage temp: 4°C, do not freeze

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