Rabbit Anti-Human TNFAIP3 monoclonal antibody for WB, ICC/IF, IHC, FC. A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor ? B (NF?B) gene expression. By inhibiting NF?B activation, A20 plays a critical role in terminating NF?B responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NF?B activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and I?B kinase (IKK) ? protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.
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