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Rabbit Anti-Human TP53 monoclonal antibody, clone TZ121-7

Cat no: DCABH-2712

Rabbit Anti-Human TP53 monoclonal antibody, clone TZ121-7

Rabbit Anti-Human TP53 monoclonal antibody for WB, ICC/IF, IHC, IP. p53, a DNA-binding, oligomerization domain- and transcription activation domain containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

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SPECIFICATIONS

Catalog Number

DCABH-2712

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TZ121-7

Target

TP53

Gene Id

7157

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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