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Rabbit Anti-Human TRX monoclonal antibody, clone KN21-120

Cat no: DCABH-2760

Rabbit Anti-Human TRX monoclonal antibody, clone KN21-120

Rabbit Anti-Human TRX monoclonal antibody for WB, ICC/IF, IHC, IP. Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx has several biological functions. It acts as a hydrogen donor for ribonucleotide reductase, which is critical for DNA synthesis, and modulates the DNA-binding activity of several transcription factors, including NFkB, AP-1, p53, TFIIIC and glucocorticoid receptor. Trx also stimulates cell growth, is an inhibitor of apoptosis and plays a role in the protection against oxidative stress. Drugs that inhibit Trx have antitumor activity, suggesting that Trx is involved in a variety of human diseases, including cancer. TrxR is a ubiquitously expressed flavoprotein that catalyzes the NADPH-dependent reduction of Trx as well as several other oxidized cellular components.

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SPECIFICATIONS

Catalog Number

DCABH-2760

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

KN21-120

Target

TRX

Gene Id

7295

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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