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Rabbit Anti-Human XRCC6 monoclonal antibody, clone KN72-42

Cat no: CABT-L949

Rabbit Anti-Human XRCC6 monoclonal antibody, clone KN72-42

Rabbit Anti-Human XRCC6 monoclonal antibody for WB, IP, ICC/IF, IHC, FC. The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (p70) and Ku-86 (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. A Ku-related protein designated the enhancer 1 binding factor (E1BF), composed of two subunits, has been identified as a positive regulator of RNA polymerase I transcription initiation.

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SPECIFICATIONS

Catalog Number

CABT-L949

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

KN72-42

Target

XRCC6

Gene Id

2547

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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