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Rabbit Anti-JNK2 monoclonal antibody, clone TD16-96

Cat no: CABT-L688

Rabbit Anti-JNK2 monoclonal antibody, clone TD16-96

Rabbit Anti-JNK2 monoclonal antibody for WB, ICC, IHC, IP, FC. c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1?1, JNK1?1, JNK2?1, JNK2?1, and JNK3?1, which represent the p46 isoforms, and JNK1?2, JNK1?2, JNK2?2, JNK2?2, and JNK3?2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38.

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SPECIFICATIONS

Catalog Number

CABT-L688

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

TD16-96

Target

JNK2

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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