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Rabbit Anti-LDLR monoclonal antibody, clone TK1208

Rabbit Anti-LDLR monoclonal antibody, clone TK1208

Cat no: CABT-L624

Supplier: Creative Diagnostics
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Rabbit Anti-LDLR monoclonal antibody for WB, ICC/IF, IHC, FC. LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDLR, LRP, Megalin, VLDLR, and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats, and an O-linked sugar domain. The LDL receptor is a cell surface transmembrane protein that mediates the uptake of low density lipoprotein and its degradation in the lysosome, which provides cholesterol to cells. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. Mutations in LDLR cause the autosomal dominant disease, familial hypercholesterolemia (FH), which promotes premature coronary atherosclerosis.
Catalogue number: CABT-L624
Reactivities: Human, Mouse
Hosts: Rabbit
Conjugates: Unconjugated
Clone: TK1208
Target: LDLR
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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