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Rabbit Anti-MAP3K3 monoclonal antibody, clone TE1940

Cat no: CABT-L813

Rabbit Anti-MAP3K3 monoclonal antibody, clone TE1940

Rabbit Anti-MAP3K3 monoclonal antibody for WB, ICC/IF, IHC, IP, FC. MAP kinase kinase kinase (MEKK3 or MAP3K3) is a serine/threonine protein kinase that activates SAPK and ERK via phosphorylation and activation of their respective MAP kinase kinases, SEK and MEK1/2. MEKK3 also stimulates MEK5 via activation of ERK5/BMK1, which is at least partly regulated by a direct interaction between MEK5 and MEKK3 via p67phox-Bem1p (PB1) protein-protein interaction domains found in both proteins. MEKK3 modulates NF-?B activation in response to a variety of agonists including TNF?, LPS, IL-1 and LPA. Despite reports showing that phosphorylation of MEKK3 at Ser526 within the activation loop is necessary for kinase activation, at least one study suggests that dual phosphorylation at Thr516 and Ser520 is required for LPA-stimulated IKK?/NF-?B activation. Phosphorylation at Thr294 appears to negatively regulate MEKK3 by promoting 14-3-3? binding and inhibition of the kinase activity.

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SPECIFICATIONS

Catalog Number

CABT-L813

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

TE1940

Target

MAP3K3

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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