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Rabbit Anti-Mouse MMP15 polyclonal antibody

Rabbit Anti-Mouse MMP15 polyclonal antibody

Cat no: CABT-L1797

Supplier: Creative Diagnostics
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Rabbit Anti-Mouse MMP15 polyclonal antibody for IHC-P. MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastasis.
Catalogue number: CABT-L1797
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Gene: 4324
Target: MMP15
Isotype: IgG
Clonality: Polyclonal
Storage temp: 2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

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