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Rabbit Anti-NFkB monoclonal antibody, clone TA31-12

Cat no: CABT-L593

Rabbit Anti-NFkB monoclonal antibody, clone TA31-12

Rabbit Anti-NFkB monoclonal antibody for WB, IHC. Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NF B (p50 and p65) and the Drosophila maternal morphagen, dorsal. These proteins share sequence homology over a region of 300 amino acids at their NH2-terminus, the region that contains their DNA binding and dimerization domains. The DNA binding activity of NF B is activated and rapidly transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins have been described. These proteins, designated p105 and p100, are highly related but map on different chromosomes. The p105 (p110) precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated PdI, binds to p50 and regulates its activity.

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SPECIFICATIONS

Catalog Number

CABT-L593

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

TA31-12

Target

NFkB

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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