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Rabbit Anti-NFkB p50 (phospho Ser337) monoclonal antibody, clone 3I8M9

Cat no: CABT-L1566

Rabbit Anti-NFkB p50 (phospho Ser337) monoclonal antibody, clone 3I8M9

Rabbit Anti-Human NFkB p50 (phospho Ser337) monoclonal antibody for FC, WB. NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.

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SPECIFICATIONS

Catalog Number

CABT-L1566

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

3I8M9

Target

RELA

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at 4В°C short term. For long term storage, store at -20В°C, avoiding freeze/thaw cycles.

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