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Rabbit Anti-PDGFRA monoclonal antibody, clone KG215-7

Cat no: DCABH-2917

Rabbit Anti-PDGFRA monoclonal antibody, clone KG215-7

Rabbit Anti-PDGFRA monoclonal antibody for WB, ICC, IHC, FC. Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-? and -?, which are endowed with protein tyrosine kinase domains. PDGFR-? can bind to both A and B subunits of PDGF, while PDGFR-? can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two ? receptors, PDGF-AB induces dimerization of ?? and ?? and PDGF-BB induces the formation of three types of dimers, ??, ?? and ??. Translocation of the PDGFR-? gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.

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SPECIFICATIONS

Catalog Number

DCABH-2917

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

KG215-7

Target

PDGFRA

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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