Rabbit Anti-PDGFRB monoclonal antibody for WB, IHC, IP. Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-? and –?, which are endowed with protein tyrosine kinase domains. PDGFR-? can bind to both A and B subunits of PDGF, while PDGFR-? can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two ? receptors, PDGF-AB induces dimerization of ?? and ?? and PDGF-BB induces the formation of three types of dimers, ??, ?? and ??. Translocation of the PDGFR-? gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.
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