Rabbit Anti-Human PKC theta (phospho Thr538) monoclonal antibody for FC, IHC-P, WB. Protein Kinase C theta of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and homeostasis. Transgenic mice over-expressing dominant negative PKC theta develop hyperinsulinimia. PKC theta is involved in JNK activation and also plays a specialized role in TCR-mediated activation of T and B cells. Through its control of Rap1, PKC theta establishes a threshold for T cell activation and positively regulates cytokine response and adhesive properties. The activation of PKC theta in T cells is associated with its recruitment to the membrane, and is mediated by PI3-kinase and Vav. PKC theta is a constitutively competent kinase and is phosphorylated on threonine 538 in the activation loop. The phosphorylation of threonine 538 is critical to PKC theta kinase activity, and plays an important role in PKC theta-mediated activation of nuclear factor kappaB.
Quick Search
Products 
