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Rabbit Anti-POU5F1 monoclonal antibody, clone TE1861

Cat no: CABT-L775

Rabbit Anti-POU5F1 monoclonal antibody, clone TE1861

Rabbit Anti-POU5F1 monoclonal antibody for WB, ICC/IF, IHC, IP, CHIP. POU5F1 (POU domain, class 5, transcription factor 1), also known as octamer-binding transcription factor-3 (Oct-3, OTF3), octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3/4, modulates embryonic stem (ES) cell populations by influencing lineage commitment. Oct-3/4 sustains stem-cell self-renewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.

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SPECIFICATIONS

Catalog Number

CABT-L775

Hosts

Rabbit

Reactivities

Hum, Mouse

Conjugates

Unconj

Clone

TE1861

Target

POU5F1

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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