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Rabbit Anti-PRKAR2A monoclonal antibody, clone TD65-15

Cat no: CABT-L696

Rabbit Anti-PRKAR2A monoclonal antibody, clone TD65-15

Rabbit Anti-PRKAR2A monoclonal antibody for WB, ICC/IF, IHC, IP. The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated C?, C? and C?, that each represent specific gene products. C? and C? are closely related (93% amino acid sequence similarity), whereas C? displays 83% and 79% similarity to C? and C?, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.

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SPECIFICATIONS

Catalog Number

CABT-L696

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

TD65-15

Target

PRKAR2A

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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