Rabbit Anti-PRKCA monoclonal antibody for WB, ICC/IF, IHC, IP. Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor-promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into many different isoforms (?, ?I, ?II, ?, ?, ?, ?, ?, ?, ?/?, ? and ?). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC ? and ? are independent of Ca. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.
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